Gas Sensing in Cells / edited by Shigetoshi Aono.

• Overview of Gas-sensing Systems / Shigetoshi Aono -- Haem-based Sensors of Nitric Oxide / D. E. Williams, J. T. Fischer, I. Heckler and E. M. Boon -- Haem-based Sensors of Dioxygen / Hitomi Sawai and Yoshitsugu Shiro -- Haem-based Sensors of Carbon Monoxide / Shigetoshi Aono -- Iron–Sulfur Cluster-based Sensors / Jason C. Crack and Nick E. Le Brun -- Nonhaem Iron-based Sensors of Reactive Oxygen and Nitrogen Species / Koichiro Ishimori and Dayeon Nam -- Mammalian O2 Sensing and Signalling / Vanessa D. Chaplin, Alexandra N. Barbato and Michael J. Knapp -- Plant Ethylene Sensing and Signalling / Arkadipta Bakshi and Brad M. Binder. 

• Gas molecules such as O₂, NO, CO and ethylene are present in the environment and are endogenously (enzymatically) produced to act as signalling molecules in biological systems, including the regulation of metabolic networks, chemotaxis, circadian rhythms, mammalian hypoxia responses, and plant ethylene responses by transcriptional, translational, or post translational control. Sensing these gas molecules is the first step in their acting as signalling molecules. When a sensor domain/protein senses an external signal, intra- and inter-molecular signal transductions take place to regulate the biological function of a regulatory domain/protein such as DNA-binding, enzymatic activity, or protein–protein interaction. Interaction between gas molecules and sensor proteins is essential for recognition of gas molecules. Metal-containing prosthetic groups such as haem, iron–sulfur clusters, and non-haem iron centres are widely used. As these metal-containing centres are good spectroscopic probes, detail characterizations have utilized spectroscopic techniques along with X-ray crystallography. Covering both the signalling and sensing of gaseous molecules, this book provides the first comprehensive overview of gas sensor proteins in both prokaryotic and eukaryotic cells. This book will be particularly interesting to postgraduates and researchers in biochemistry, molecular biology and metallobiology. 

Ämnesord

Cells  (LCSH)

Gas detectors  (LCSH)

Indexterm och SAB-rubrik

Ue.039 Biologi: cytologi (cellbiologi)

Klassifikation

571.6 (DDC)

Ue.039 (kssb/8)