Reduced serum levels of autoantibodies against monomeric C-reactive protein (CRP) in patients with acute coronary syndrome [Elektronisk resurs]
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Wetterö, Jonas (författare)
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Nilsson, Lennart (författare)
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Jonasson, Lena (författare)
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Sjöwall, Christoffer (författare)
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- Linköpings universitet Institutionen för klinisk och experimentell medicin (utgivare)
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Alternativt namn: IKE
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Alternativt namn: Linköping University. Department of Clinical and Experimental Medicine
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Alternativt namn: Linköping University. Faculty of Health Sciences. Department of Clinical and Experimental Medicine
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Linköpings universitet Hälsouniversitetet (utgivare)
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- Linköpings universitet Institutionen för medicin och hälsa (utgivare)
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Alternativt namn: IMH
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Alternativt namn: Engelska: Linköping Universty. Department of Medical and Health Sciences
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Alternativt namn: Linköping Universty. Department of Medicine and Health Sciences
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Se även: Linköpings universitet. Institutionen för hälsa och samhälle
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Se även: Linköpings universitet. Institutionen för medicin och vård
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Östergötlands Läns Landsting Hjärtcentrum (utgivare)
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Östergötlands Läns Landsting Medicincentrum (utgivare)
- 2009
- Engelska.
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Ingår i: Clinica Chimica Acta. - 0009-8981. ; 400:1-2, 128-131
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Sammanfattning
Ämnesord
Stäng
- Introduction: Inflammation is pivotal in atherosclerosis. Minor C-reactive protein (CRP) response reflects low-grade vascular inflammation and the high-sensitivity CRP test with levels >= 3.0 mg/l predicts coronary vascular events and survival in angina pectoris as well as in healthy subjects. We and others recently reported autoantibodies against monomeric CRP (anti-CRP) in rheumatic conditions, e.g. systemic lupus erythematosus (SLE), and a connection between anti-CRP and cardiovascular disease in SLE has been suggested. Patients and methods: Anti-CRP serum levels were determined with ELISA in 140 individuals; 50 healthy controls and 90 patients with angiographically verified coronary artery disease of which 40 presented with acute coronary syndrome (ACS) and 50 with stable angina pectoris (SA). Results: Significantly lower anti-CRP levels were observed in ACS compared to SA and controls (p=0.019). ACS patients, who had not been prescribed statins before their respective cardiovascular event, had lower anti-CRP (p = 0.049). BMI correlated directly to anti-CRP levels in cross section analysis (p = 0.043), but there was no association between anti-CRP and smoking or cholesterol. Discussion: In ACS, it is plausible that ruptured plaques and inflamed tissue may be more prone to opsonization by monomeric CRP leading to consumption of anti-CRP, Hypothetically, surface-bound anti-CRP could thereby enhance the local inflammation in plaques.
Ämnesord
- Medical and Health Sciences (hsv)
- Medicin och hälsovetenskap (hsv)
- MEDICINE (svep)
- MEDICIN (svep)
Indexterm och SAB-rubrik
- Anti-CRP antibody
- Atherosclerosis
- C-reactive protein
- Coronary artery disease
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