Prostate cancer sensor [Elektronisk resurs] combining Raman spectroscopy and tactile resonance technology

• 83%) porcine samples was 82% using TRM data alone. It increased to 87% while using the combined data sets of TRM and RS. For discerning healthy and cancerous human prostate tissue, the cross-validation accuracy was 67% and 77% for TRM alone versus TRM and RS combined.Paper C covered a number of design considerations which have to be addressed during the combination of TRM and RS. The effects of attaching an RS probe into a tubular TRM element were investigated. We investigated the temperature increase caused by the laser illumination from the RS and its eect on the TRM measurement parameter Δf. We also investigated if and how RS could be performed under ambient light. A thin RS probe and a small amount of rubber latex was preferable for attaching the RS probe inside the TRM sensor. The temperature rise of the TRM sensor due to a fibreoptic NIR-RS at 270 mWduring 20 s was less than 2ºC. The variation of Δf during a 5ºC temperature change was approximately 20 Hz. This is small compared to previous in vitro TRM studies. Fibre-optic NIR-RS was feasible in a dimmed bright environment using a small light shield and automatic subtraction of a pre-recorded contaminant spectrum. The results of these studies indicate how the hardware and and software could be combined into one integrated probe for prostate cancer detection. 

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Medical Engineering  (hsv)

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