Regulation of oxygen tension as a strategy to control chondrocytic phenotype for cartilage tissue engineering and regeneration [Elektronisk resurs]

• Cartilage defects and osteoarthritis are health problems which are major burdens on health care systems globally, especially in aging populations. Cartilage is a vulnerable tissue, which generally faces a progressive degenerative process when injured. This makes it the 11th most common cause of global disability. Conservative methods are used to treat the initial phases of the illness, while orthopedic management is the method used for more progressed phases. These include, for instance, arthroscopic shaving, microfracturing and mosaicplasty, and joint replacement as the final treatment. Cell-based implantation methods have also been developed. Despite reports of successful treatments, they often suffer from the non-optimal nature of chondrocyte phenotype in the repair tissue. Thus, improved strategies to control the phenotype of the regenerating cells are needed. Avascular tissue cartilage relies on diffusion for nutrients acquisition and the removal of metabolic waste products. A low oxygen content is also present in cartilage, and the chondrocytes are, in fact, well adapted to it. Therefore, this raises an idea that the regulation of oxygen tension could be a strategy to control the chondrocyte phenotype expression, important in cartilage tissue for regenerative purposes. This narrative review discusses the aspects related to oxygen tension in the metabolism and regulation of articular and growth plate chondrocytes and progenitor cell phenotypes, and the role of some microenvironmental factors as regulators of chondrocytes. 

Ämnesord

Medical and Health Sciences  (hsv)

Basic Medicine  (hsv)

Cell and Molecular Biology  (hsv)

Medicin och hälsovetenskap  (hsv)

Medicinska och farmaceutiska grundvetenskaper  (hsv)

Cell- och molekylärbiologi  (hsv)

Medical Biotechnology  (hsv)

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)  (hsv)

Medicinsk bioteknologi  (hsv)

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)  (hsv)

Natural Sciences  (hsv)

Biological Sciences  (hsv)

Biochemistry and Molecular Biology  (hsv)

Naturvetenskap  (hsv)

Biologiska vetenskaper  (hsv)

Biokemi och molekylärbiologi  (hsv)

Cell Biology  (hsv)

Cellbiologi  (hsv)

Engineering and Technology  (hsv)

Medical Engineering  (hsv)

Medical Materials  (hsv)

Teknik och teknologier  (hsv)

Medicinteknik  (hsv)

Medicinska material och protesteknik  (hsv)

biologisk kemi  (umu)

biological chemistry  (umu)

cellforskning  (umu)

cell research  (umu)

Medical Cell Biology  (umu)

medicinsk cellbiologi  (umu)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

cartilage

oxygen tension

tissue engineering