Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes [Elektronisk resurs]

• Introduction: Pregnancy entails both pancreatic adaptations with increasing beta-cell mass and immunological alterations in healthy women. In this study, we have examined the effects of pregnancy on beta-cell function and immunological processes in long-standing type 1 diabetes (L-T1D). Research design and methods: Fasting and stimulated C-peptide were measured after an oral glucose tolerance test in pregnant women with L-T1D (n=17) during the first trimester, third trimester, and 5-8 weeks post partum. Two 92-plex Olink panels were used to measure proteins in plasma. Non-pregnant women with L-T1D (n=30) were included for comparison. Results: Fasting C-peptide was detected to a higher degree in women with L-T1D during gestation and after parturition (first trimester: 64.7%, third trimester: 76.5%, and post partum: 64.7% vs 26.7% in non-pregnant women). Also, total insulin secretion and peak C-peptide increased during pregnancy. The plasma protein levels in pregnant women with L-T1D was dynamic, but few analytes were functionally related. Specifically, peripheral levels of prolactin (PRL), prokineticin (PROK)-1, and glucagon (GCG) were elevated during gestation whereas levels of proteins related to leukocyte migration (CCL11), T cell activation (CD28), and antigen presentation (such as CD83) were reduced. Conclusions: In summary, we have found that some C-peptide secretion, that is, an indirect measurement of endogenous insulin production, is regained in women with L-T1D during pregnancy, which might be attributed to elevated peripheral levels of PRL, PROK-1, or GCG. 

Ämnesord

Medical and Health Sciences  (hsv)

Clinical Medicine  (hsv)

Endocrinology and Diabetes  (hsv)

Medicin och hälsovetenskap  (hsv)

Klinisk medicin  (hsv)

Endokrinologi och diabetes  (hsv)

Basic Medicine  (hsv)

Immunology in the medical area  (hsv)

Medicinska och farmaceutiska grundvetenskaper  (hsv)

Immunologi inom det medicinska området  (hsv)

Obstetrics, Gynecology and Reproductive Medicine  (hsv)

Reproduktionsmedicin och gynekologi  (hsv)

Endocrinology and Diabetology  (uu)

Endokrinologi och Diabetologi  (uu)

Obstetrik och gynekologi  (uu)

Obstetrics and Gynaecology  (uu)

Biology with specialization in Molecular Immunology  (uu)

Biologi med inriktning mot molekylär immunologi  (uu)

Klinisk immunologi  (uu)

Clinical Immunology  (uu)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

Type 1 diabetes

pregnancy

β-cell function

prolactin

prokineticin-1

glucagon

immunomodulation