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Postoperative symptoms after gynaecological surgery how they are influenced by prophylactic antiemetics sensory stimulation (P6-acupressure) / Aidah Alkaissi.

Alkaissi, Aidah, 1953- (författare)
Lundberg, Dag (opponent)
Linköpings universitet Institutionen för medicin och hälsa (utgivare)
Linköpings universitet Hälsouniversitetet (utgivare)
Östergötlands Läns Landsting Anestesi- och operationscentrum (utgivare)
Publicerad: Linköping : Linköping University Electronic Press, 2004
Engelska 1 onlineresurs (79 sidor)
Serie: Linköping University Medical Dissertations, 0345-0082 0345-0082 ; 851
Läs hela texten (Sammanfattning och ramberättelse från Linköping University Electronic Press)
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  • E-bokAvhandling(Diss. (sammanfattning) Linköping : Linköpings universitet, 2004)
Sammanfattning Ämnesord
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  • Symptoms after surgery and anaesthesia influence the patient´s ability to resume daily activities. If postoperative symptoms are controlled rehabilitation may be accelerated. The aims of this dissertation were to identify disturbing symptoms reported by patients after gynaecological surgery, to investigate what effect prohylactic treatment with antiemetics has on these symptoms and whether or not sensory simulation of the P6-acupressure has an effect on postoperative nausea and vomiting (PONV) and motion sickness. Methods: Total 1138 women participated in three clinical trials (Studies I, II, III) and one experimental study (Study IV). A questionnaire investigating postoperative symptoms was constructed and validated. The questionnaire was used in a prospective, consecutive, doubleblind, randomised, multicentre, and controlled study to identify incidence, and intensity of postoperative symptoms and the effect of common antiemetics (droperidol and granisetron) (Study III). The patients were followed for 24 h. In two studies (I, II) P6-acupressure was compared (prospective, double-blind, ransomised, controlled) with placebo acupressure and a reference group where the effect on PONV was followed over 24 h. The effect of P6-acupressure and placebo acupressure on motion sickness induced by a nauseogenic motion challenge was studied (Study III). Results: A high incidence and severity of postoperative symptoms were found after gynaecological surgery in a group with a high risk (>30%) for PONV. Sixty-four per cent (107/165) of the patients experienced disturbing symptoms after surgery and 46 % (76/165) scored their symptoms as moderate to very severe. Fourty-eight per cent (79/165) had two or more symptoms. A higher incidence of symptoms were reported in the groups with prophylactic treatment, granisetron 74% (123/165) and droperidol 80% (133/165) compared to the control group 41% (69/165) (P <0.05). The relative risk reduction for PONV with granisetron or droperidol prophylaxis is 27% respective 22%. The relative risk increase for headache is 63% after granisetron, and 44% for difficulty with accommodation after droperidol. Less PONV was seen after P6-acupressure, 33% (44/135) compared to reference group 46% (63/136) (p = 0.019), number needed to treat (NNT) was 7 [95% confidence interval (CI) 4- 6]. When comparing laparoscopic and vaginal surgery (subgroup analysis) the main effect was in the vaginal group (day-case surgery), 36% (27/75) in the reference group to 27% (23/86) in the placebo group and to 20% (17/84) in the P6-acupressure group, (P = 0.017), NNT for the vaginal group was 6 [95% CI 3-18]. P6-acupressure increased time to nausea after a laboratory motion challenge and reduced the total number of symptoms reported (p <0.009). Conclusions: There is no clinical efficacy in the form of reduced postoperative symptoms after prophylactic antiemetics (droperidol and granisetron) in females with a high risk (>30%) for PONV undergoing gynaecological surgery. P6-acupressure reduces the incidence of PONV after gynaecological surgery in females with a high (>30%) risk for PONV. The effect seems to be most prominent after vaginal surgery. P6-acupressure increased tolerance to experimental nausogenic stimuli and reduced the total number of symptoms reported in females with a history of motion sickness. 

Ämnesord

Acupuncture therapy  (MeSH)
Gynecologic surgical procedures  (MeSH)
Acupressure  -- methods (MeSH)
Antiemetics  -- administration (MeSH)
Antiemetics  -- therapeutic use (MeSH)
Postoperative nausea and vomiting  -- prevention & control (MeSH)
Postoperative nausea and vomiting  -- therapy (MeSH)
Postoperative nausea and vomiting  -- drug therapy (MeSH)
Motion sickness  -- therapy (MeSH)
Medical and Health Sciences  (ssif)
Clinical Medicine  (ssif)
Anesthesiology and Intensive Care  (ssif)
Medicin och hälsovetenskap  (ssif)
Klinisk medicin  (ssif)
Anestesi och intensivvård  (ssif)
MEDICINE  (svep)
Surgery  (svep)
Anaesthetics and intensive care  (svep)
Anaesthetics  (svep)
MEDICIN  (svep)
Kirurgi  (svep)
Anestesiologi och intensivvård  (svep)
Anestesiologi  (svep)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

Acupuncture
P6-acupressure
droperidol
antiemetics
PONV
gynaecological surgery
motion sickness
eccentric rotation
coriolis effect
antiemetic prophylaxis
granisetron
Vfd Anestesi
Vg Gynekologi och andrologi
Vma Fysioterapi. Sjukgymnastik

Klassifikation

617.96 (DDC)
612.6 (DDC)
615.82 (DDC)
Vfd (kssb/7)
Vg (kssb/7)
Vma (kssb/7)
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