IPN Hydrogels Based on Nanocellulose for Soft Tissue Engineering [Elektronisk resurs]

E-bokEngelska2015

Förlag, utgivningsår, omfång ...

2015

Nummerbeteckningar

LIBRIS-ID:22197565
http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-31412uri
urn:nbn:se:ltu:diva-31412urn
5961b0d5-39cb-4355-bd53-e77bdc0e77dd

Kompletterande språkuppgifter

Språk:engelska

Ingår i deldatabas

deldatabas:Eplk_tEPLK

Anmärkningar

<p>Godkänd; 2015; 20160821 (narnas)</p>
gratis
In tissue engineering, development of materials, which positively interact with tissues, is very important.1 In this regard, hydrogels composed of three-dimensional polymeric networks, have become more attractive materials due to their ability to absorb high water content and swells without losing their structural integrity.2 Furthermore, hydrogels need to provide physico-mechanical support for cell growth, proliferation and new tissue formation.3 However, their low mechanical properties have found one drawback4 and therefore in this study, cellulose nanocrystals (CNCBE) isolated from bioethanol residue were used as reinforcement or functional additive. The objective of this work was to develop double-crosslinked Interpenetrating Polymeric Networks (IPNs) of nanocellulose-based hydrogels on alginate and gelatin and investigate the effect of IPN processing route on physico-chemical properties of the produced hydrogels as well as their potential in soft tissue engineering. Fully bio-based porous IPN scaffolds were processed through two freeze-drying steps and crosslinked using calcium chloride and genipin. The second freeze-drying was performed to induce more pores in the structure. The morphology studies showed highly porous structure (90-97% porosity), which is beneficial for cell attachment and growth, but resulted in lower mechanical performances under compression. Addition of CNCBE and crosslinking decreased the moisture uptake while increased the compression modulus. Furthermore, the development of extracellular matrix (ECM) is expected to improve the mechanical performances after implantation.AcknowledgementsFinancial support from VINNOVA (No. 2011-02071) under MNT-ERANET project, n-POSSCOG is acknowledged. References1. Silva, S. S.; Motta, A.; Rodrigues, M. T.; Pinheiro, A. F.; Gomes, M. E.; Mano, J. F.; Reis, R. L.; Migliaresi, C. Biomacromolecules 2008, 9, 2764-2774.2. Dragan, E. S.; Perju, M. M.; Dinu, M. V. Carbohydr. Polym. 2012, 88, 270-281.3. Drury, J. L.; Mooney, D. J. Biomaterials 2003, 24, 4337-4351.4. Matricardi, P.; Di Meo, C.; Coviello, T.; Hennink, W. E.; Alhaique, F. Adv. Drug Deliv. Rev. 2013, 65, 1172-1187.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

Deepa, B. (författare)
Bárcena, José R. (författare)
Mathew, Aji P. (författare)
Oksman, Kristiina (författare)
Luleå tekniska universitetInstitutionen för teknikvetenskap och matematik (utgivare)

Sammanhörande titlar

Del av/supplement till:channel record

Internetlänk

Länka till posten

Inställningar Hjälp

Uppgift om bibliotek saknas i LIBRIS

Kontakta ditt bibliotek, eller sök utanför LIBRIS. Se högermenyn.

1 av 1
Föregående post
Nästa post
Till träfflistan

Sök utanför LIBRIS

Hjälp

Sök vidare i:: Google; Google Book Search; Google Scholar; LibraryThing

Om LIBRIS: Sekretess

Hjälp: Fel i posten?; Kontakt; Teknik och format

Sök utifrån: Sökrutor; Plug-ins; Bookmarklet

Anpassa: Textstorlek; Kontrast; Vyer

LIBRIS söktjänster: SwePub; Uppsök

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.