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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07731naa a22015253a 4500 | |
| 001 | n1723lgrl9kqq9k2 | |
| 003 | SE-LIBR | |
| 005 | 20210115132253.0 | |
| 007 | cr ||| ||||| | |
| 008 | 210115s2020 sw |||||o||||o000 ||eng|c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1787292 uri |
| 024 | 7 | a urn:nbn:se:umu:diva-1787292 urn |
| 024 | 7 | a 10.1186/s12916-020-01855-92 doi |
| 040 | a Se a | |
| 041 | a eng | |
| 042 | 9 EPLK | |
| 100 | 1 | a Bull, Caroline J.4 aut |
| 245 | 1 0 | a Adiposity, metabolites, and colorectal cancer riskh [Elektronisk resurs]b Mendelian randomization study |
| 264 | 1 | b BMC,c 2020 |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or by sex is unclear. Further, the metabolic alterations mediating the effects of adiposity on CRC are not fully understood. Methods We examined sex- and site-specific associations of adiposity with CRC risk and whether adiposity-associated metabolites explain the associations of adiposity with CRC. Genetic variants from genome-wide association studies of body mass index (BMI) and waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), and 123 metabolites from targeted nuclear magnetic resonance metabolomics (N = 24,925), were used as instruments. Sex-combined and sex-specific Mendelian randomization (MR) was conducted for BMI and WHR with CRC risk (58,221 cases and 67,694 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry). Sex-combined MR was conducted for BMI and WHR with metabolites, for metabolites with CRC, and for BMI and WHR with CRC adjusted for metabolite classes in multivariable models. Results In sex-specific MR analyses, higher BMI (per 4.2 kg/m(2)) was associated with 1.23 (95% confidence interval (CI) = 1.08, 1.38) times higher CRC odds among men (inverse-variance-weighted (IVW) model); among women, higher BMI (per 5.2 kg/m(2)) was associated with 1.09 (95% CI = 0.97, 1.22) times higher CRC odds. WHR (per 0.07 higher) was more strongly associated with CRC risk among women (IVW OR = 1.25, 95% CI = 1.08, 1.43) than men (IVW OR = 1.05, 95% CI = 0.81, 1.36). BMI or WHR was associated with 104/123 metabolites at false discovery rate-corrected P <= 0.05; several metabolites were associated with CRC, but not in directions that were consistent with the mediation of positive adiposity-CRC relations. In multivariable MR analyses, associations of BMI and WHR with CRC were not attenuated following adjustment for representative metabolite classes, e.g., the univariable IVW OR for BMI with CRC was 1.12 (95% CI = 1.00, 1.26), and this became 1.11 (95% CI = 0.99, 1.26) when adjusting for cholesterol in low-density lipoprotein particles. Conclusions Our results suggest that higher BMI more greatly raises CRC risk among men, whereas higher WHR more greatly raises CRC risk among women. Adiposity was associated with numerous metabolic alterations, but none of these explained associations between adiposity and CRC. More detailed metabolomic measures are likely needed to clarify the mechanistic pathways. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Health Sciences2 hsv |
| 650 | 7 | a Nutrition and Dietetics2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Hälsovetenskaper2 hsv |
| 650 | 7 | a Näringslära2 hsv |
| 653 | a Body mass index | |
| 653 | a Waist-to-hip ratio | |
| 653 | a Colorectal cancer | |
| 653 | a Mendelian randomization | |
| 653 | a Metabolism | |
| 653 | a NMR | |
| 653 | a Epidemiology | |
| 653 | a GECCO | |
| 653 | a CORECT | |
| 653 | a CCFR | |
| 655 | 7 | a government publication2 marcgt |
| 700 | 1 | a Bell, Joshua A.4 aut |
| 700 | 1 | a Murphy, Neil4 aut |
| 700 | 1 | a Sanderson, Eleanor4 aut |
| 700 | 1 | a Davey Smith, George4 aut |
| 700 | 1 | a Timpson, Nicholas J.4 aut |
| 700 | 1 | a Banbury, Barbara L.4 aut |
| 700 | 1 | a Albanes, Demetrius4 aut |
| 700 | 1 | a Berndt, Sonja I.4 aut |
| 700 | 1 | a Bezieau, Stephane4 aut |
| 700 | 1 | a Bishop, D. Timothy4 aut |
| 700 | 1 | a Brenner, Hermann4 aut |
| 700 | 1 | a Buchanan, Daniel D.4 aut |
| 700 | 1 | a Burnett-Hartman, Andrea4 aut |
| 700 | 1 | a Casey, Graham4 aut |
| 700 | 1 | a Castellvi-Bel, Sergi4 aut |
| 700 | 1 | a Chan, Andrew T.4 aut |
| 700 | 1 | a Chang-Claude, Jenny4 aut |
| 700 | 1 | a Cross, Amanda J.4 aut |
| 700 | 1 | a de la Chapelle, Albert4 aut |
| 700 | 1 | a Figueiredo, Jane C.4 aut |
| 700 | 1 | a Gallinger, Steven J.4 aut |
| 700 | 1 | a Gapstur, Susan M.4 aut |
| 700 | 1 | a Giles, Graham G.4 aut |
| 700 | 1 | a Gruber, Stephen B.4 aut |
| 700 | 1 | a Gsur, Andrea4 aut |
| 700 | 1 | a Hampe, Jochen4 aut |
| 700 | 1 | a Hampel, Heather4 aut |
| 700 | 1 | a Harrison, Tabitha A.4 aut |
| 700 | 1 | a Hoffmeister, Michael4 aut |
| 700 | 1 | a Hsu, Li4 aut |
| 700 | 1 | a Huang, Wen-Yi4 aut |
| 700 | 1 | a Huyghe, Jeroen R.4 aut |
| 700 | 1 | a Jenkins, Mark A.4 aut |
| 700 | 1 | a Joshu, Corinne E.4 aut |
| 700 | 1 | a Keku, Temitope O.4 aut |
| 700 | 1 | a Kuhn, Tilman4 aut |
| 700 | 1 | a Kweon, Sun-Seog4 aut |
| 700 | 1 | a Le Marchand, Loic4 aut |
| 700 | 1 | a Li, Christopher I.4 aut |
| 700 | 1 | a Li, Li4 aut |
| 700 | 1 | a Lindblom, Annika4 aut |
| 700 | 1 | a Martin, Vicente4 aut |
| 700 | 1 | a May, Anne M.4 aut |
| 700 | 1 | a Milne, Roger L.4 aut |
| 700 | 1 | a Moreno, Victor4 aut |
| 700 | 1 | a Newcomb, Polly A.4 aut |
| 700 | 1 | a Offit, Kenneth4 aut |
| 700 | 1 | a Ogino, Shuji4 aut |
| 700 | 1 | a Phipps, Amanda I.4 aut |
| 700 | 1 | a Platz, Elizabeth A.4 aut |
| 700 | 1 | a Potter, John D.4 aut |
| 700 | 1 | a Qu, Conghui4 aut |
| 700 | 1 | a Quiros, J. Ramon4 aut |
| 700 | 1 | a Rennert, Gad4 aut |
| 700 | 1 | a Riboli, Elio4 aut |
| 700 | 1 | a Sakoda, Lori C.4 aut |
| 700 | 1 | a Schafmayer, Clemens4 aut |
| 700 | 1 | a Schoen, Robert E.4 aut |
| 700 | 1 | a Slattery, Martha L.4 aut |
| 700 | 1 | a Tangen, Catherine M.4 aut |
| 700 | 1 | a Tsilidis, Kostas K.4 aut |
| 700 | 1 | a Ulrich, Cornelia M.4 aut |
| 700 | 1 | a van Duijnhoven, Franzel J. B.4 aut |
| 700 | 1 | a van Guelpen, Bethany4 aut |
| 700 | 1 | a Visvanathan, Kala4 aut |
| 700 | 1 | a Vodicka, Pavel4 aut |
| 700 | 1 | a Vodickova, Ludmila4 aut |
| 700 | 1 | a Wang, Hansong4 aut |
| 700 | 1 | a White, Emily4 aut |
| 700 | 1 | a Wolk, Alicja4 aut |
| 700 | 1 | a Woods, Michael O.4 aut |
| 700 | 1 | a Wu, Anna H.4 aut |
| 700 | 1 | a Campbell, Peter T.4 aut |
| 700 | 1 | a Zheng, Wei4 aut |
| 700 | 1 | a Peters, Ulrike4 aut |
| 700 | 1 | a Vincent, Emma E.4 aut |
| 700 | 1 | a Gunter, Marc J.4 aut |
| 710 | 1 | a Umeå universitetb Medicinska fakulteten4 pbl |
| 710 | 1 | a Umeå universitetb Medicinska fakulteten4 pbl |
| 772 | 0 8 | i channel recordw tc5g1zj51493sl0 |
| 773 | 0 | t BMC Medicineg 18:1x 1741-7015 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178729 |
| 856 | 4 0 | u http://dx.doi.org/10.1186/s12916-020-01855-9 |
| 856 | 4 0 | u http://umu.diva-portal.org/smash/get/diva2:1517677/FULLTEXT01 |
| 856 | 4 2 | u http://www.umu.se/z Värdpublikation |
| 887 | a {"@id":"n1723lgrl9kqq9k2","modified":"2021-01-15T13:22:53.65+01:00","checksum":"90389886829"}2 librisxl | |
| 841 | 5 APISa x ab 210115||0000|||||001||||||000000e u | |
| 024 | 7 | 5 APISa urn:nbn:se:umu:diva-1787292 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178729 |
| 887 | 5 APISa {"@id":"9nvpq73k718xm24t","modified":"2021-01-15T13:22:53.712+01:00","checksum":"119487354476"}2 librisxl |
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- Castellvi-Bel, Sergi
- Chan, Andrew T.
- Chang-Claude, Jenny
- Cross, Amanda J.
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- Figueiredo, Jane C.
- Gallinger, Steven J.
- Gapstur, Susan M.
- Giles, Graham G.
- Gruber, Stephen B.
- Gsur, Andrea
- Hampe, Jochen
- Hampel, Heather
- Harrison, Tabitha A.
- Hoffmeister, Michael
- Hsu, Li
- Huang, Wen-Yi
- Huyghe, Jeroen R.
- Jenkins, Mark A.
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- Keku, Temitope O.
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- Lindblom, Annika
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- Rennert, Gad
- Riboli, Elio
- Sakoda, Lori C.
- Schafmayer, Clemens
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- Slattery, Martha L.
- Tangen, Catherine M.
- Tsilidis, Kostas K.
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- van Duijnhoven, Fran ...
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