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2451 0a Molecular anatomy of cellular systemsh [Elektronisk resurs] /c [edited by] I. Endo, T. Kudo, H. Osada, T. Shibata and I. Yamaguchi.
264 1a Amsterdam :b Elsevier science,c 2002
300 a online resource (vi, 231 s.b ill.)
490a Progress in Biotechnology,x 2212-117X ;v 22
500 a e-bok
505a Part I Cellular functions -- Stress meets development in p38 MAP kinase /Tatsuhiko Sudo, Masumi Maruyama, Hiroyuki Osada -- Molecular dissection of cytotoxic functions mediated by T cells /Takao Kataoka, Kazuo Nagai -- Molecular imaging of the cytoskeleton using GFP-actin fluorescence microscopy /Yuling Yan, Gerard Marriott -- Golgi-acting drugs: inducers and inhibitors of Golgi dispersal as probes to analyze Golgi membrane dynamics /Takatsuki Akira -- Regulation of protein sorting and trafficking between the endoplasmic reticulum and the Golgi apparatus in yeast /Akihiko Nakano -- An unexpected gift from fungicide metabolism studies: blasticidin S deaminase (BSD) from Aspergillus terreus /Makoto Kimura, Masaki Yamamoto, Makio Furuichi, Takashi Kumasaka, Isamu Yamaguchi -- Isolation and analysis of genes from phytopathogenic fungi /Takayuki Motoyama, Tsutomu Arie, Takashi Kamakura, Isamu Yamaguchi -- A novel type of Na/H antiporter: its unique characteristics and function /Saori Kosono, Makio Kitada, Toshiaki Kudo -- Part II Nuclear functions -- Genetic analysis of the genes involved in mitosis in fission yeast Schizosaccharomyces pombe /Yukinobu Nakaseko, Mitsuhiro Yanagida -- Intergenomic transcriptional interplays between plastid as a cyanobacterial symbiont and nucleus /Hideo Takahashi, Kan Tanaka -- From viral RNA genome to infectious ribonucleoprotein complexes through RNA replication /Kyosuke Nagata -- Mechanisms of regulation of eukaryotic homologous DNA recombination /Takehiko Shibata, Ken-ichi Mizuno, Kunihiro Ohta -- Part III Protein functions -- Studies on photoreactive enzyme-nitrile hydratase /Isao Endo, Masafumi Odaka -- Structural and functional analyses of proteins involved in translation, DNA recombination, chromosome architecture, and signal transduction /Hitoshi Kurumizaka, Shigeyuki Yokoyama -- The importance of the hydrophobic pocket in actin subdomain 4 for Ca2+-activation of actin-activated myosin ATPase in the presence of Tropomyosin-Troponin /Takeyuki Wakabayashi, Takuo Yasunaga, Kimiko Saeki, Yoshiyuki Matsuura -- Physiological functions and molecular structures of new types of hemoproteins /Yoshitsugu Shiro, Yasuhiro Isogai, Hiro Nakamura, Tetsutaro Iizuka -- Unity and diversity in biological oxidation /Johannis A. Duine
520 a In this book, the progress during the last ten years is reviewed and future plans outlined to realize and establish the concept of design in the biological sciences. Design is a leading concept as well as the principal motivation for the creation of artificial systems. A successful design generally requires that the structures and functions of the elements that constitute the system as well as the principles that determine how the elements cooperate together to create function be fully understood. These requirements have not been satisfied within the fields of biotechnology and medicine. Compared to the recent emergence of artificial systems, living organisms acquired their present day structures and functions through evolution over three to four billion years. Despite the fact that the design of living organisms is recorded in the DNA sequence, our understanding of the structures and functions of the elements that constitute living organisms is very limited. To fulfill the requirements, the following approaches were initiated under a ten-year project entitled "Biodesign Research". Firstly, we tried to isolate and characterize the functional elements that constitute the organelles of various organisms. Secondly, we tried to reconstitute systems that reproduce biological functions in vitro from individual elements in order to understand how the elements cooperate together to yield a function. Thirdly, we attempted to resolve biological structures at various resolutions ranging from the atomic to the cellular level to further our knowledge about the fundamental principles that various functions at the molecular level and to design artificial systems.
599 a WaSeSS
700a Endo, Isao4 edt
700a Kudo, T.4 edt
700a Osada, H.4 edt
700a Shibata, T.4 edt
700a Yamaguchi, I.4 edt
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