Uridine, 4-thiouridine and isomaltitol in an asthma-like model Anti-inflammatory and modulating effects / Chamilly Evaldsson.
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Evaldsson, Chamilly, 1978- (författare)
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Uppugunduri, Srinivas (preses)
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Linden, Margareta (opponent)
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Linköpings universitet Institutionen för klinisk och experimentell medicin (utgivare)
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Linköpings universitet Hälsouniversitetet (utgivare)
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Östergötlands Läns Landsting Laboratoriemedicinskt centrum (utgivare)
- Publicerad: Linköping : Linköping University Electronic Press, 2009
- Engelska 1 onlineresurs (85 sidor)
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Serie: Linköping University Medical Dissertations, 0345-0082 0345-0082
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- Relaterad länk:
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http://www.liu.se (Värdpublikation)
Sammanfattning
Ämnesord
Stäng
- In chronic inflammatory diseases like asthma or rheumatoid arthritis, erroneous and exaggerated accumulation of leukocytes in a tissue inadvertently causes the body harm. Several efficient anti-inflammatory drugs exist, for example corticosteroids and cyclo-oxygenase inhibitors. However, these drugs have potent and diverse effects and often act by inhibiting events subsequent to initiation of the inflammatory response, leading to more or less severe side-effects, especially when used in high doses for long periods of time. For this reason, strategies aimed at early inhibition of recruitment and activation of leukocytes have been suggested as safer and more specific approaches to reduce inflammation. Leukocyte adhesion to activated endothelium is a prerequisite to the following activation and extravasation, and takes place in the initial phase of inflammation. By using a model that allows leukocytes to adhere to tumour necrosis factor (TNF)-activated endothelial cells, thus mimicking aspects of an inflammatory reaction, we found that uridine, 4-thiouridine and isomaltitol could all reduce adhesion. This suggested that they may have anti-inflammatory potential. We therefore tried the three substances in a Sephadex-induced lung inflammation model and found that uridine and 4-thiouridine have several anti-inflammatory effects, such as being able to reduce leukocyte accumulation, decrease TNF protein levels and partly inhibit the oedema induced by Sephadex. Isomaltitol turned out to have immunomodulating, rather than anti-inflammatory, effects, which could be of interest in diseases where inadequate inflammatory responses are a problem.
Ämnesord
- Anti-inflammatory agents -- pharmacology (MeSH)
- Anti-inflammatory agents -- therapeutic use (MeSH)
- Cell adhesion -- drug effects (MeSH)
- Leukocytes -- drug effects (MeSH)
- Lung -- pathology (MeSH)
- Pneumonia -- pathology (MeSH)
- Pneumonia -- prevention & control (MeSH)
- Polysaccharides -- toxicity (MeSH)
- Pulmonary edema -- prevention & control (MeSH)
- Thiouridine -- pharmacology (MeSH)
- Thiouridine -- therapeutic use (MeSH)
- Tumor necrosis factor-alpha -- biosynthesis (MeSH)
- Uridine -- pharmacology (MeSH)
- Medical and Health Sciences (ssif)
- Basic Medicine (ssif)
- Pharmacology and Toxicology (ssif)
- Medicin och hälsovetenskap (ssif)
- Medicinska och farmaceutiska grundvetenskaper (ssif)
- Farmakologi och toxikologi (ssif)
- Medical and Health Sciences (ssif)
- Medicin och hälsovetenskap (ssif)
- Medical and Health Sciences (ssif)
- Clinical Medicine (ssif)
- Respiratory Medicine and Allergy (ssif)
- Medicin och hälsovetenskap (ssif)
- Klinisk medicin (ssif)
- Lungmedicin och allergi (ssif)
- PHARMACY (svep)
- Pharmaceutical pharmacology (svep)
- FARMACI (svep)
- Farmaceutisk farmakologi (svep)
- MEDICINE (svep)
- MEDICIN (svep)
- MEDICINE (svep)
- Dermatology and venerology,clinical genetics, internal medicine (svep)
- Internal medicine (svep)
- Lung diseases (svep)
- MEDICIN (svep)
- Dermatologi och venerologi, klinisk genetik, invärtesmedicin (svep)
- Invärtesmedicin (svep)
- Lungsjukdomar (svep)
Genre
- government publication (marcgt)
Indexterm och SAB-rubrik
- Uridine
- asthma
- 4-thiouridine
- isomaltitol
- isomalt
- inflammation
- eosinophilia
- Sephadex
- animal model
- rat
- Vebr Immunologiska sjukdomar
Klassifikation
- 616.97 (DDC)
- Vebr (kssb/8)
Inställningar
Hjälp
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