Short-Term Exposure to Ozone Does Not Impair Vascular Function or Affect Heart Rate Variability in Healthy Young Men [Elektronisk resurs]

Barath, Stefan 1963- (författare)

Langrish, Jeremy P. (författare)

Lundbäck, Magnus 1976- (författare)

Alternativt namn: Lundbäck, Cardiovascular effects of exposure to diesel exhaust [Elektronisk resurs] : mechanistic and interventional studies / Magnus Lundbäck Umeå : Umeå university,, 1976-

Bosson, Jenny 1975- (författare)

Goudie, Colin (författare)

Newby, David, E (författare)

Sandström, Thomas 1957- (författare)

Mills, Nicholas, L (författare)

Blomberg, Anders 1961- (författare)

Umeå universitet Medicinska fakulteten (utgivare)

Alternativt namn: Umeå universitet. Medicinsk-odontologiska fakulteten

Alternativt namn: Medicinska fakulteten vid Umeå universitet

Oxford University Press 2013
Engelska.
Ingår i: Toxicological Sciences. - 1096-6080. ; 135:2, 292-299

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Air pollution exposure is associated with cardiovascular morbidity and mortality, yet the role of individual pollutants remains unclear. In particular, there is uncertainty regarding the acute effect of ozone exposure on cardiovascular disease. In these studies, we aimed to determine the effect of ozone exposure on vascular function, fibrinolysis, and the autonomic regulation of the heart. Thirty-six healthy men were exposed to ozone (300 ppb) and filtered air for 75min on two occasions in randomized double-blind crossover studies. Bilateral forearm blood flow (FBF) was measured using forearm venous occlusion plethysmography before and during intra-arterial infusions of vasodilators 2–4 and 6–8h after each exposure. Heart rhythm and heart rate variability (HRV) were monitored during and 24h after exposure. Compared with filtered air, ozone exposure did not alter heart rate, blood pressure, or resting FBF at either 2 or 6h. There was a dose-dependent increase in FBF with all vasodilators that was similar after both exposures at 2–4h. Ozone exposure did not impair vasomotor or fibrinolytic function at 6–8h but rather increased vasodilatation to acetylcholine ( p = .015) and sodium nitroprusside ( p = .005). Ozone did not affect measures of HRV during or after the exposure. Our findings do not support a direct rapid effect of ozone on vascular function or cardiac autonomic control although we cannot exclude an effect of chronic exposure or an interaction between ozone and alternative air pollutants that may be responsible for the adverse cardiovascular health effects attributed to ozone.

Ämnesord

Medical and Health Sciences (hsv)
Clinical Medicine (hsv)
Cardiac and Cardiovascular Systems (hsv)
Medicin och hälsovetenskap (hsv)
Klinisk medicin (hsv)
Kardiologi (hsv)
MEDICINE (svep)
Dermatology and venerology,clinical genetics, internal medicine (svep)
Internal medicine (svep)
MEDICIN (svep)
Dermatologi och venerologi, klinisk genetik, invärtesmedicin (svep)
Invärtesmedicin (svep)
Cardiology (umu)
kardiologi (umu)
lungmedicin (umu)
Lung Medicine (umu)
Environmental Science (umu)
miljövetenskap (umu)

Indexterm och SAB-rubrik

Air Pollution
blood flow
endothelium
fibrinolysis
oxidative stress
ozone
Luftföroreningar

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Short-Term Exposure to Ozone Does Not Impair Vascular Function or Affect Heart Rate Variability in Healthy Young Men [Elektronisk resurs]

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