The Biological Chemistry of Nickel / edited by Deborah Zamble, Magdalena Rowińska-Żrek and Henryk Kozłowski.

• Introduction to the Biological Chemistry of Nickel / Deborah Zamble -- Oceanic Nickel Biogeochemistry and the Evolution of Nickel Use / J. B. Glass and C. L. Dupont -- Nickel Toxicity and Carcinogenesis / Jason Brocato and Max Costa -- Nickel Binding Sites : Coordination Modes and Thermodynamics / Magdalena Rowińska-Żyrek and Henryk Kozłowski -- Urease / L. Mazzei, F. Musiani and S. Ciurli -- Crystallographic Analyses of the Active Site Chemistry and Oxygen Sensitivity of [NiFe(Se)]-Hydrogenases / A. Volbeda and J. C. Fontecilla-Camps -- One-Carbon Chemistry of Nickel-Containing Carbon Monoxide Dehydrogenase and Acetyl-CoA Synthase / Yan Kung and Catherine L. Drennan -- Biochemistry of Methyl-Coenzyme M Reductase / Stephen W. Ragsdale, Simone Raugei, Bojana Ginovska and Thanyaporn Wongnate -- Reinventing the Wheel: The NiSOD Story / Julius O. Campeciño and Michael J. Maroney -- Nickel Glyoxalase I / J. F. Honek -- Lactate Racemase and Its Niacin-Derived, Covalently-Tethered, Nickel Cofactor / Benoît Desguin, Patrice Soumillion, Pascal Hols, Jian Hu and Robert P. Hausinger -- Nickel in Microbial Physiology : from Single Proteins to Complex Trafficking Systems: Nickel Import/Export / Agnes Rodrigue, Marta Albareda, Marie-Andrée Mandrand-Berthelot and Jose Palacios -- Nickel Regulation / Peter T. Chivers -- Nickel Metallochaperones: Structure, Function, and Nickel-Binding Properties / Wei Xia, Hongyan Li and Hongzhe Sun -- Cross-Talk Between Nickel and Other Metals in Microbial Systems / D. H. Nies, J. Covès and R. G. Sawers -- Nickel and Virulence in Bacterial Pathogens / Hilde de Reuse -- Application of Ni2+-Binding Proteins / J. Zakrzewska-Czerwińska and A. M. Zawilak-Pawlik. 

• Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry. 

Ämnesord

Nickel  (LCSH)

Biochemistry  (LCSH)

Nickel industry  (LCSH)

Indexterm och SAB-rubrik

Uceaz Särskilda grundämnen

Klassifikation

572.52625 (DDC)

Uceaz nickel (kssb/8)