2-Oxoglutarate-Dependent Oxygenases / [editors] Robert Hausinger, Christopher Schofield.

• Biochemical Diversity of 2-Oxoglutarate-Dependent Oxygenases / Robert P. Hausinger -- Introduction to Structural Studies on 2-Oxoglutarate-Dependent Oxygenases and Related Enzymes / Wei Shen Aik, Rasheduzzaman Chowdhury, Ian J. Clifton, Richard J. Hopkinson, Thomas Leissing, Michael A. McDonough, Radosław Nowak, Christopher J. Schofield and Louise J. Walport -- Mechanisms of 2-Oxoglutarate-Dependent Oxygenases: The Hydroxylation Paradigm and Beyond / J. Martin Bollinger Jr., Wei-chen Chang, Megan L. Matthews, Ryan J. Martinie, Amie K. Boal and Carsten Krebs -- Synthetic Models of 2-Oxoglutarate-Dependent Oxygenases / Caleb J. Allpress, Scott T. Kleespies and Lawrence Que Jr -- Collagen Hydroxylases / Johanna Myllyharju -- The Role of 2-Oxoglutarate-Dependent Oxygenases in Hypoxia Sensing / Sarah E. Wilkins, Emily Flashman, John S. Scotti, Richard J. Hopkinson, Rasheduzzaman Chowdhury and Christopher J. Schofield -- JmjC Lysine Demethylases / Xiaodong Cheng and Raymond C. Trievel -- AlkB and Its Homologues : DNA Repair and Beyond / Tina A. Müller and Robert P. Hausinger -- RNA Demethylation by FTO and ALKBH5 / Guanqun Zheng and Chuan He -- Role of ALKBH8 in the Synthesis of Wobble Uridine Modifications in tRNA / Pål Ø. Falnes and Angela Yeuan Yen Ho -- The TET/JBP Family of Nucleic Acid Base-Modifying 2-Oxoglutarate and Iron-Dependent Dioxygenases / L. Aravind, Dapeng Zhang and Lakshminarayan M. Iyer -- 2-Oxoglutarate-Dependent Hydroxylases Involved in DNA Base J (β-D-Glucopyranosyloxymethyluracil) Synthesis / David Reynolds, Laura Cliffe and Robert Sabatini -- Dioxygenases of Carnitine Biosynthesis: 6-N-Trimethyllysine and γ-Butyrobetaine Hydroxylases / Frédéric M. Vaz and Naomi van Vlies -- Phytanoyl-CoA Hydroxylase: A 2-Oxoglutarate-Dependent Dioxygenase Crucial for Fatty Acid Alpha-Oxidation in Humans / Ronald J. A. Wanders, Sacha Ferdinandusse, Merel S. Ebberink and Hans R. Waterham -- Role of 2-Oxoglutarate-Dependent Oxygenases in Flavonoid Metabolism / Stefan Martens and Ulrich Matern -- Gibberellin Metabolism / Peter Hedden and Andrew L. Phillips -- 2-Oxoglutarate-Dependent Oxygenases of Cephalosporin Synthesis / Inger Andersson and Karin Valegård -- Recent Advances in the Structural and Mechanistic Biology of Non-Haem Fe(ii), 2-Oxoglutarate and O2-Dependent Halogenases / Janet L. Smith and Dheeraj Khare -- Isopenicillin N Synthase / Peter J. Rutledge -- 1-Aminocyclopropane-1-Carboxylic Acid Oxidase / A. Jalila Simaan and Marius Réglier -- 4-Hydroxyphenylpyruvate Dioxygenase and Hydroxymandelate Synthase: 2-Oxo Acid-Dependent Oxygenases of Importance to Agriculture and Medicine / Dhara D. Shah and Graham R. Moran. 

• Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases. 

Ämnesord

Oxygenases  (LCSH)

Genre

Electronic books. 

Klassifikation

571.791 (DDC)

Ue.044 (kssb/8 (machine generated))