Metal-based Anticancer Agents / edited by Angela Casini, Anne Vessières, Samuel M. Meier-Menches.

• PART 1: MAIN CLASSES OF METAL-BASED ANTICANCER AGENTS AND THEIR MODES OF ACTION -- Enhancing the Therapeutic Potential of Platinum-based Anticancer Agents by Incorporating Clinically Approved Drugs as Ligands / Reece G. Kenny and Celine J. Marmion -- Ruthenium, Osmium and Iridium in the Fight Against Cancer / Isolda Romero-Canelón -- Iron Compounds as Anticancer Agents / Anne Vessieres -- Recent Advances in Anticancer Copper Compounds / Andrew Kellett, Zara Molphy, Vickie McKee and Creina Slator -- Anticancer Gold Compounds / Di Hu, Chun-Nam Lok and Chi-Ming Che -- Heterometallic Complexes as Anticancer Agents / Natalia Curado and Maria Contel -- Vanadium Compounds as Enzyme Inhibitors with a Focus on Anticancer Effects / Debbie C. Crans, Noah E. Barkley, Liliana Montezinho and M. Margarida Castro -- Arsenic-based Anticancer Agents / Stéphane Gibaud -- PART 2. ENABLING CONCEPTS IN METALLODRUG DISCOVERY -- Supramolecular Metal-based Structures for Applications in Cancer Therapy / Margot N. Wenzel, Benjamin Woods and Angela Casini -- Enabling Methods to Elucidate the Effects of Metal-based Anticancer Agents / D. Kreutz, C. Gerner and S. M. Meier-Menches -- PART 3. PRECLINICAL AND CLINICAL EVALUATION -- Metal-based Radiotherapeutics / Christian A. Mason, Lukas M. Carter and Jason S. Lewis -- Challenges and Chances in the Preclinical to Clinical Translation of Anticancer Metallodrugs / Isabella Pötsch, Dina Baier, Bernhard K. Keppler and Walter Berger. 

• Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging concepts and enabling methods, as well as presenting key pre-clinical and clinical aspects. Recent progress on the unique features of next-generation targeted metal-based anticancer agents, including supramolecular coordination complexes used for both therapy and drug delivery, promise a bright future beyond the benefits of pure cytotoxic activity. With contributions from global leaders in the field, this book will serve as a useful reference to established researchers as well as a practical guide to those new to metallodrugs, and postgraduate students of medicinal chemistry and metallobiology. 

Ämnesord

Antineoplastic agents.  (LCSH)

Metals  -- Therapeutic use. (LCSH)

Klassifikation

615.23 (DDC)

Vd (kssb/8 (machine generated))