Pooling ambulatory saliva cortisol samples over consecutive days – as reliable as arithmetic means [Elektronisk resurs]
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Garvin, Peter 1976- (författare)
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Carstensen, John (författare)
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Kristenson, Margareta (författare)
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- Linköpings universitet Institutionen för hälsa och samhälle (utgivare)
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Alternativt namn: Linköpings universitet. Department of Health and Society
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Alternativt namn: Linköping University. Department of Health and Society
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Se även: Linköpings universitet. Institutionen för medicin och hälsa
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Linköpings universitet Hälsouniversitetet (utgivare)
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- Linköpings universitet Institutionen för medicin och hälsa (utgivare)
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Alternativt namn: IMH
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Alternativt namn: Engelska: Linköping Universty. Department of Medical and Health Sciences
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Alternativt namn: Linköping Universty. Department of Medicine and Health Sciences
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Se även: Linköpings universitet. Institutionen för hälsa och samhälle
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Se även: Linköpings universitet. Institutionen för medicin och vård
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- Linköpings universitet Filosofiska fakulteten (utgivare)
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Alternativt namn: Linköping University. Faculty of Arts and Sciences
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Se även: Universitetet i Linköping. Filosofiska fakulteten
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Landstinget i Östergötland; Centre for Public Health Sciences; Centre for Public Health Sciences; Folkhälsovetenskapligt centrum; Folkhälsovetenskapligt centrum (medarbetare)
- 2008
- Engelska.
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Ingår i: Scandinavian Journal of Clinical and Laboratory Investigation. - 0036-5513. ; 68:6, 508-512
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Sammanfattning
Ämnesord
Stäng
- Objective: When cortisol measurements are to be studied in large populations, cost-effective analyses are needed. This study aimed at testing whether one pooled cortisol value over three consecutive days is as reliable as using the arithmetic mean of the samples from the same measure points. Material and methods: Thirty participants aged between 45 and 69 collected saliva in salivettes immediately after awakening (t 1 ), 30 min after awakening (t 2 ) and in the evening (t 3 ) during 3 consecutive days. A fixed volume from each of the samples (t 1 , t 2 and t 3 ) was pooled prior to laboratory analysis. Mean levels over 3 days for t 1 , t 2 and t 3 were compared to corresponding levels of pooled vials. Cortisol levels were analysed using a radio immunoassay. Results: All measures tested had high correlations between mean values and pooled samples, exemplified with diurnal deviation rdif t 2–t3 50.974 (CI 0.946;0.987), and awakening response r dif t 2–t1 50.982 (CI 0.963;0.991). There were no statistical differences between the pooled values and the arithmetic means. Conclusion: Pooling samples gave as reliable results as arithmetic means did. Pooling samples prior to laboratory analysis is a cost-effective method for measuring general diurnal cortisol variation in field research projects.
Ämnesord
- Medical and Health Sciences (hsv)
- Medicin och hälsovetenskap (hsv)
- MEDICINE (svep)
- MEDICIN (svep)
Indexterm och SAB-rubrik
- Cortisol
- HPA-axis
- measurements
- methodology
- saliva
- stress
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