Plasma Levels of Rifampin Correlate with the Tuberculosis Drug Activity Assay [Elektronisk resurs]

• The plasma tuberculosis drug activity (TDA) assay may be an alternative tool for therapeutic drug monitoring in resource-limited settings. In tuberculosis (TB) patients (n = 30), TDA and plasma levels of first-line drugs were analyzed 2 h post-dose, 2 weeks after treatment initiation. Patients with plasma levels of rifampin lower than 8 mg/liter had a significantly lower median TDA (1.40 versus 1.68, P = 0.0013). TDA may be used to identify TB patients with suboptimal rifampin levels during TB treatment. 

Ämnesord

Medical and Health Sciences  (ssif)

Basic Medicine  (ssif)

Pharmacology and Toxicology  (ssif)

Medicin och hälsovetenskap  (ssif)

Medicinska och farmaceutiska grundvetenskaper  (ssif)

Farmakologi och toxikologi  (ssif)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

pharmacokinetics; Mycobacterium tuberculosis; rifampin; isoniazid