Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors [Elektronisk resurs]
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Remes, Tiina M. (författare)
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Hovén, Emma (författare)
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Ritari, Niina (författare)
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Pohjasniemi, Heli (författare)
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Puosi, Riina (författare)
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Arikoski, Pekka M. (författare)
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Arola, Mikko O. (författare)
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Lähteenmäki, Päivi M. (författare)
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Lönnqvist, Tuula R. I. (författare)
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Ojaniemi, Marja K. (författare)
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Riikonen, V. Pekka (författare)
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Sirkiä, Kirsti H. (författare)
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Winqvist, Satu (författare)
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Rantala, Heikki M. J. (författare)
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Harila, Marika (författare)
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Harila-Saari, Arja H. (författare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
- Publicerad: 2021
- Engelska.
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Ingår i: Neuro-Oncology Practice. - 2054-2577. ; 8:3, 266-277
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Sammanfattning
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- Background Little is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated adult survivors of childhood BT and the relationship between cognitive functions and employment and social status. Methods Neurocognitive profiles of survivors were assessed in a Finnish national cohort of 71 radiotherapy-treated survivors of childhood BT (median follow-up time: 21 years [range: 5-33 years]) using a cross-sectional design. Neurocognitive outcomes were compared to control (n = 45) and normative values. Tumor- and treatment-related data were collected from the patient files. Information on employment and social status was gathered. Results Survivors’ (median age: 27 years [range: 16-43 years]) median verbal and performance intelligence quotient (IQ) was 90 (range: 49-121) and 87 (range: 43-119), respectively. The cognitive domains with the greatest impairment were executive functions (median z score, −3.5 SD [range: −25.0 to 1.3 SD]), and processing speed and attention (median z score, −2.5 SD [range: −24.9 to 0.5 SD]). Executive functions were associated with employment, educational level, living independently, having an intimate relationship, and having a driving license. Processing speed and attention were related to educational level, living independently, having an intimate relationship, and having a driving license. Performance IQ was associated with educational level and employment status. Working memory was associated with educational level and living independently. Conclusions Radiotherapy-treated adult survivors of childhood BT experience significant neurocognitive impairment, which is associated with difficulties related to employment and social status.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Neurology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Neurologi (hsv)
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cancer and Oncology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Cancer och onkologi (hsv)
Genre
- government publication (marcgt)
Indexterm och SAB-rubrik
- brain tumor
- employment
- neurocognitive impairment
- radiation
- social status
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Neuro-Oncology Practice