Using the Disease State Fingerprint Tool for Differential Diagnosis of Frontotemporal Dementia and Alzheimer's Disease [Elektronisk resurs]
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Munoz-Ruiz, Miguel Angel (författare)
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Hall, Anette (författare)
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Mattila, Jussi (författare)
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Koikkalainen, Juha (författare)
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Herukka, Sanna-Kaisa (författare)
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Husso, Minna (författare)
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Hanninen, Tuomo (författare)
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Vanninen, Ritva (författare)
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Liu, Yawu (författare)
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Hallikainen, Merja (författare)
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Lotjonen, Jyrki (författare)
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Remes, Anne M. (författare)
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Alafuzoff, Irina (författare)
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Soininen, Hilkka (författare)
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Hartikainen, Paivi (författare)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
- 2016
- Engelska.
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Ingår i: Dementia and geriatric cognitive disorders extra. ; 6:2, 313-329
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- Background: Disease State Index (DSI) and its visualization, Disease State Fingerprint (DSF), form a computer-assisted clinical decision making tool that combines patient data and compares them with cases with known outcomes. Aims: To investigate the ability of the DSI to diagnose frontotemporal dementia (FTD) and Alzheimer's disease (AD). Methods: The study cohort consisted of 38 patients with FTD, 57 with AD and 22 controls. Autopsy verification of FTD with TDP-43 positive pathology was available for 14 and AD pathology for 12 cases. We utilized data from neuropsychological tests, volumetric magnetic resonance imaging, single-photon emission tomography, cerebrospinal fluid biomarkers and the APOE genotype. The DSI classification results were calculated with a combination of leave-one-out cross-validation and bootstrapping. A DSF visualization of a FTD patient is presented as an example. Results: The DSI distinguishes controls from FTD (area under the receiver-operator curve, AUC = 0.99) and AD (AUC = 1.00) very well and achieves a good differential diagnosis between AD and FTD (AUC = 0.89). In subsamples of autopsy-confirmed cases (AUC = 0.97) and clinically diagnosed cases (AUC = 0.94), differential diagnosis of AD and FTD performs very well. Conclusions: DSI is a promising computer-assisted biomarker approach for aiding in the diagnostic process of dementing diseases. Here, DSI separates controls from dementia and differentiates between AD and FTD.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Neurology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Neurologi (hsv)
Indexterm och SAB-rubrik
- Alzheimer's disease
- Frontotemporal dementia
- Computer-assisted diagnosis
- Magnetic resonance imaging
- Neuropsychology
- Single-photon emission tomography
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