Effective ICP reduction by decompressive craniectomy in patients with severe traumatic brain injury treated by an ICP-targeted therapy [Elektronisk resurs]
-
Olivecrona, Magnus (författare)
-
Rodling Wahlström, Marie (författare)
-
Naredi, Silvana (författare)
-
Koskinen, Lars-Owe D (författare)
-
- Umeå universitet Medicinska fakulteten (utgivare)
-
-
Alternativt namn: Umeå universitet. Medicinsk-odontologiska fakulteten
-
Alternativt namn: Medicinska fakulteten vid Umeå universitet
-
- Umeå universitet Medicinska fakulteten (utgivare)
-
-
Alternativt namn: Umeå universitet. Medicinsk-odontologiska fakulteten
-
Alternativt namn: Medicinska fakulteten vid Umeå universitet
- 2007
- Engelska.
-
Ingår i: Journal of Neurotrauma. - 0897-7151. ; 24:6, 927-935
-
Läs hela texten
-
Läs hela texten
-
Läs hela texten
-
Läs hela texten
Sammanfattning
Ämnesord
Stäng
- Severe traumatic brain injury (TBI) is one of the major causes of death in younger age groups. In Umea, Sweden, an intracranial pressure (ICP) targeted therapy protocol, the Lund concept, has been used in treatment of severe TBI since 1994. Decompressive craniectomy is used as a protocol-guided treatment step. The primary aim of the investigation was to study the effect of craniectomy on ICP changes over time in patients with severe TBI treated by an ICP-targeted protocol. In this retrospective study, all patients treated for severe TBI during 1998-2001 who fulfilled the following inclusion criteria were studied: GCS <or= 8 at intubation and sedation, first recorded cerebral perfusion pressure (CPP) of >10 mm Hg, arrival within 24 h of trauma, and need of intensive care for >72 h. Craniectomy was performed when the ICP could not be controlled by evacuation of hematomas, sedation, ventriculostomy, or low-dose pentothal infusion. Ninety-three patients met the inclusion criteria. Mean age was 37.6 years. Twenty-one patients underwent craniectomy as a treatment step. We found a significant reduction of the ICP directly after craniectomy, from 36.4 mm Hg (range, 18-80 mm Hg) to 12.6 mm Hg (range, 2-51 mm Hg). During the following 72 h, we observed an increase in ICP during the first 8-12 h after craniectomy, reaching approximately 20 mm Hg, and later levelling out at approximately 25 mm Hg. The reduction of ICP was statistically significant during the 72 h. The outcome as measured by Glasgow Outcome Scale (GOS) did not significantly differ between the craniectomized group (DC) and the non-craniectomized group (NDC). The outcome was favorable (GOS 5-4) in 71% in the craniectomized group, and in 61% in the non-craniectomized group. Craniectomy is a useful tool in achieving a significant reduction of ICP overtime in TBI patients with progressive intracranial hypertension refractory to medical therapy. The procedure seems to have a satisfactory effect on the outcome, as demonstrated by a high rate of favorable outcome and low mortality in the craniectomized group, which did not significantly differ compared with the non-craniectomized group.
Indexterm och SAB-rubrik
- Adolescent
- Adult
- Aged
- Brain Injuries/complications/*physiopathology/*surgery
- Clinical Protocols/standards
- Craniotomy/*methods/standards
- Emergency Medical Services/methods/standards
- Female
- Humans
- Intracranial Hypertension/etiology/*physiopathology/*surgery
- Male
- Middle Aged
- Patient Selection
- Postoperative Complications/prevention & control
- Skull/*surgery
- Time Factors
- Treatment Outcome
Inställningar
Hjälp
Beståndsinformation saknas