Polymorphism of the human complement component C3- genetic and immunological aspects [Elektronisk resurs] / by Rolf Brönnestam.

• Genetic polymorphism is by definition the occurrence inthe same population of two or more alleles at one locus,each with a frequency high enough not to be maintained byrecurrent mutation only (1). Among the human plasmaproteins two major categories of polymorphism have beendescribed, allotypic and electrophoretic heterogeneity.Allotypy is defined by Oudin as individual antigenic differencesamong proteins within a species (2). The firstdiscovered polymorphism of this category was the Gm systemof immunoglobulin G by Grubb (3). The first describedelectrophoretic heterogeneity in plasma proteins was theHp (haptoglobin) system discovered by Smithies (4). Sincethen genetic variants of several other human plasma proteinshave been found. This dissertation is concerned with thegenetic and immunological aspects of the polymorphism ofthe third component of human complement, C3. 

Ämnesord

Complement  (MeSH)

Medical Biotechnology  (ssif)

Medicinsk bioteknologi  (ssif)

Genre

government publication  (marcgt)

Klassifikation

610 (DDC)

V (kssb)