Functional Diversity of AAA plus Protease Complexes in Bacillus subtilis [Elektronisk resurs]
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Elsholz, Alexander K. W. (författare)
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Birk, Marlene S. (författare)
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Charpentier, Emmanuelle, 1968- (författare)
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Turgay, Kuersad (författare)
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Umeå universitet Medicinska fakulteten (utgivare)
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Umeå universitet Medicinska fakulteten (utgivare)
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Umeå universitet Medicinska fakulteten (utgivare)
- Publicerad: Frontiers Media S.A. 2017
- Engelska.
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Ingår i: ; 4
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- Relaterad länk:
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http://www.umu.se/ (Värdpublikation)
Sammanfattning
Ämnesord
Stäng
- Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis. We discuss in detail the intricate involvement of AAA+ protein complexes in controlling sporulation, the heat shock response and the role of adaptor proteins in these processes. The investigation of these protein complexes and their adaptor proteins has revealed their relevance for Gram-positive pathogens and their potential as targets for new antibiotics.
Ämnesord
- Natural Sciences (hsv)
- Biological Sciences (hsv)
- Biochemistry and Molecular Biology (hsv)
- Naturvetenskap (hsv)
- Biologiska vetenskaper (hsv)
- Biokemi och molekylärbiologi (hsv)
Genre
- government publication (marcgt)
Indexterm och SAB-rubrik
- AAA plus protease complexes
- Hsp100/Clp proteins
- Bacillus subtilis
- protein quality control
- chaperones
- regulatory proteolysis
- McsB
- adaptor proteins
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