Randomized comparison of early supplemental oxygen versus ambient air in patients with confirmed myocardial infarction [Elektronisk resurs] Sex-related outcomes from DETO2X-AMI
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Alfredsson, J. (författare)
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James, S. K. (författare)
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Erlinge, D. (författare)
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Herlitz, Johan, 1949- (författare)
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Fröbert, O. (författare)
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Dworeck, C. (författare)
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Redfors, B. (författare)
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Arefalk, G. (författare)
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Östlund, O. (författare)
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Jernberg, T. (författare)
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Mars, K. (författare)
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Haaga, U. (författare)
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Lindahl, B. (författare)
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Swahn, E. (författare)
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Lawesson, S. S. (författare)
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Hofmann, R. (författare)
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Investigators, for the DETO2X-SWEDEHEART (författare)
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PreHospen (medarbetare)
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Högskolan i Borås Akademin för vård, arbetsliv och välfärd (utgivare)
- Publicerad: Mosby Inc. 2021
- Engelska.
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Ingår i: American Heart Journal. - 0002-8703. ; 237, 13-24
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- Relaterad länk:
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http://www.hb.se/ (Värdpublikation)
Sammanfattning
Ämnesord
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- Background : The purpose of this study is to investigate the impact of oxygen therapy on cardiovascular outcomes in relation to sex in patients with confirmed myocardial infarction (MI). Methods : The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction trial randomized 6,629 patients to oxygen at 6 L/min for 6-12 hours or ambient air. In the present subgroup analysis including 5,010 patients (1,388 women and 3,622 men) with confirmed MI, we report the effect of supplemental oxygen on the composite of all-cause death, rehospitalization with MI, or heart failure at long-term follow-up, stratified according to sex. Results : Event rate for the composite endpoint was 18.1% in women allocated to oxygen, compared to 21.4% in women allocated to ambient air (hazard ratio [HR] 0.83, 95% confidence interval [CI] 0.65-1.05). In men, the incidence was 13.6% in patients allocated to oxygen compared to 13.3% in patients allocated to ambient air (HR 1.03, 95% CI 0.86-1.23). No significant interaction in relation to sex was found (P=.16). Irrespective of allocated treatment, the composite endpoint occurred more often in women compared to men (19.7 vs 13.4%, HR 1.51; 95% CI, 1.30-1.75). After adjustment for age alone, there was no difference between the sexes (HR 1.06, 95% CI 0.91-1.24), which remained consistent after multivariate adjustment. Conclusion: Oxygen therapy in normoxemic MI patients did not significantly affect all-cause mortality or rehospitalization for MI or heart failure in women or men. The observed worse outcome in women was explained by differences in baseline characteristics, especially age
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cardiac and Cardiovascular Systems (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Kardiologi (hsv)
- Människan i vården (hb)
- The Human Perspective in Care (hb)
Genre
- government publication (marcgt)
Indexterm och SAB-rubrik
- acetylsalicylic acid
- angiotensin receptor antagonist
- beta adrenergic receptor blocking agent
- calcium channel blocking agent
- clopidogrel
- dipeptidyl carboxypeptidase inhibitor
- diuretic agent
- oxygen
- prasugrel
- ticagrelor
- acute heart infarction
- adult
- aged
- all cause mortality
- ambient air
- Article
- cardiovascular function
- cause of death
- clinical outcome
- comparative study
- controlled study
- female
- follow up
- heart failure
- hospital readmission
- hospitalization
- human
- incidence
- long term care
- major clinical study
- male
- outcome assessment
- oxygen saturation
- oxygen supply
- oxygen therapy
- population
- priority journal
- randomized controlled trial
- sex difference
- ST segment elevation myocardial infarction
- treatment indication
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American Heart Journal