Down regulation of Fc and complement receptors on B cells in rheumatoid arthritis [Elektronisk resurs]

• B cell tolerance is regulated by receptors that modulate B cell receptor signaling, such as Fc gamma receptor IIb (FcγRIIb; CD32b) and complement receptors (CR) 1 and 2. Deficiency in these receptors may contribute to autoimmunity. To address this we have investigated the receptor expression in healthy individuals in comparison with rheumatoid arthritis (RA) patients. In healthy subjects we found that women had overall lower Fcgamma;RIIb expression on B cells than men that significantly decreased with age. RA patients had fewer FcγRIIb, CR1 and CR2 positive B cells and decreased receptor expressions compared to healthy subjects. Further, the RA B cells displayed a significantly increased proliferative response when cultured with interleukin-2 in vitro. In summary, the dysregulated B cells in RA are associated with lower FcγRIIb, CR1 and CR2 levels. The reduced FcγRIIb expression on B cells in women may influence the increased frequency of autoimmunity in women. 

Ämnesord

Medical and Health Sciences  (ssif)

Clinical Medicine  (ssif)

Rheumatology and Autoimmunity  (ssif)

Medicin och hälsovetenskap  (ssif)

Klinisk medicin  (ssif)

Reumatologi och inflammation  (ssif)

MEDICINE  (svep)

Dermatology and venerology,clinical genetics, internal medicine  (svep)

Internal medicine  (svep)

Rheumatology  (svep)

MEDICIN  (svep)

Dermatologi och venerologi, klinisk genetik, invärtesmedicin  (svep)

Invärtesmedicin  (svep)

Reumatologi  (svep)

Immunologi  (uu)

Immunology  (uu)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

B cells

Fc receptor

Complement receptor

Autoimmunity

Rheumatoid arthritis