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Sökning: onr:s30q23wdqf8ww5n5 > Frk/Shb Signalling ...

Frk/Shb Signalling in Pancreatic Beta-cells [Elektronisk resurs] Roles in Islet Function, Beta-cell Development and Survival as Implicated in Mouse Knockout Models

Åkerblom, Björn, 1976- (författare)
Welsh, Michael (preses)
Mulder, Hindrik (opponent)
Michael Welsh (medarbetare)
Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet (utgivare)
Publicerad: Uppsala : Acta Universitatis Upsaliensis, 2009
Engelska 58
Serie: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 1651-6206
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  • E-bokAvhandling(Diss. (sammanfattning) Uppsala : Uppsala universitet, 2009)
Sammanfattning Ämnesord
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  • The adaptor protein Shb and the non-receptor tyrosine kinase Frk have been implicated in intracellular signalling in insulin-producing beta cells. In this thesis, knockout mice are used to further elucidate the role of Shb and Frk for beta cell number, cytokine-induced cell death, and glucose homeostasis. In addition, the effect of Shb deficiency upon tumour growth is studied in a mouse model of endogenous tumourigenesis. Previously, overexpression of Frk has been associated with increased beta cell replication, and increased susceptibility to cytokine induced beta cell destruction. To test whether Frk has a non-redundant role in regulating beta cell mass, beta cell number in Frk-/- mice was assessed at different stages of life. The results showed that Frk is involved in regulating beta cell number during embryonal and early postnatal life, but is probably redundant in the adult. An earlier study had suggested that Shb participates in cytokine-induced beta cell death, a model of autoimmune diabetes. To test this further, Shb-/- islets were exposed to cytokines, or to an ER-stress inducing agent. Shb knockout islets exhibited decreased cell death, and this effect appeared to be independent of NO, JNK, p38 MAP kinase, FAK and c-Abl, but may involve an augmented induction of Hsp70. Furthermore, glucose homeostasis in Shb-/- mice was impaired, with elevated basal blood sugar concentration and reduced glucose-induced insulin secretion. Previously Shb deficient mice had showed an impaired ability to sustain growth of implanted tumour cells, due to reduced angiogenesis. Tumour growth and angiogenesis were here assessed in an inheritable tumour model. Shb deficient mice exhibited fewer tumours, and reduced vessel density in small tumours, indicating impaired angiogenesis. However, a few large tumours developed in Shb-/- mice, suggesting that tumours can escape the angiogenic restriction caused by the absence of Shb. 

Ämnesord

Medical and Health Sciences  (hsv)
Basic Medicine  (hsv)
Cell and Molecular Biology  (hsv)
Medicin och hälsovetenskap  (hsv)
Medicinska och farmaceutiska grundvetenskaper  (hsv)
Cell- och molekylärbiologi  (hsv)
MEDICINE  (svep)
Morphology, cell biology, pathology  (svep)
Cell biology  (svep)
Medical cell biology  (svep)
MEDICIN  (svep)
Morfologi, cellbiologi, patologi  (svep)
Cellbiologi  (svep)
Medicinsk cellbiologi  (svep)
medicinsk cellbiologi  (uu)
Medical Cell Biology  (uu)

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government publication  (marcgt)
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