Startsida
Hjälp
Sök i LIBRIS databas

     

 

Sökning: onr:22151910 > Isomaltitol exacerb...

  • Evaldsson, Chamilly1978- (författare)

Isomaltitol exacerbates neutrophilia but reduces eosinophilia [Elektronisk resurs]New insights into the Sephadex model of lung inflammation

  • E-artikel/E-kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • Karger2011

Nummerbeteckningar

  • LIBRIS-ID:22151910
  • http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19097uri
  • urn:nbn:se:liu:diva-19097urn
  • 10.1159/000321820doi

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Anmärkningar

  • Original Publication: Chamilly Evaldsson, Ingvar Rydén and Srinivas Uppugunduri, Isomaltitol exacerbates neutrophilia but reduces eosinophilia: New insights into the Sephadex model of lung inflammation, 2011, International Archives of Allergy and Immunology, (154), 4, 286-294. http://dx.doi.org/10.1159/000321820 Copyright: S. Karger AG http://www.karger.com/
  • Published
  • gratis
  • We have previously examined isomaltitol in an in vitro static adhesion assay between isolated granulocytes and cultured human umbilical cord vein cells and were interested in investigating whether the potentially anti-inflammatory effects observed there could be reproduced in vivo. The Sephadex-induced lung inflammation model was considered a suitable model due to the significant changes in global inflammatory endpoints, like oedema and leukocyte migration, usually seen upon provocation with Sephadex. Male Sprague-Dawley rats were instilled intratracheally with Sephadex (5 mg/ml), vehicle (0.9% NaCl), isomaltitol (50 mg/ml) or a combination of isomaltitol and Sephadex. After 24 h, the lungs were weighed to measure oedema and preserved for histology. Bronchoalveolar lavage fluid was used for analysis of tumour necrosis factor, cysteinyl leukotrienes, and differential and total leukocyte counts. In addition, blood differential counts and thymus weights were analysed. Contrary to what we expected from in vitro experiments, differential counts showed that isomaltitol increased the neutrophil component while decreasing the eosinophilia. Isomaltitol thus asserted a modulatory role on the usually eosinophil-dominated Sephadex-induced cell profile. Isomaltitol alone also increased several inflammatory parameters, including oedema and cysteinyl leukotrienes, and generally aggravated total inflammation in combination with Sephadex. Although the mechanisms were not investigated in this study, the effects could relate to a combination of isomaltitol's osmotic and structure-specific properties. Our results indicate that isomaltitol can modulate the inflammatory response induced by Sephadex instillation in addition to have pro-inflammatory effects on it its own, and may therefore provide new insights into the mechanisms of this widely used animal model. Sugar alcohols similar to isomaltitol have already been used to aid mucus clearance in cystic fibrosis patients, and it is possible that isomaltitol could also be used for this purpose.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Rydén, Ingvar (författare)
  • Uppugunduri, Srinivas (författare)
  • Linköpings universitetInstitutionen för klinisk och experimentell medicin (utgivare)
  • Linköpings universitetHälsouniversitetet (utgivare)
  • Östergötlands Läns LandstingDiagnostikcentrum (utgivare)

Sammanhörande titlar

  • Del av/supplement till:channel record
  • Ingår i:VärdpublikationInternational Archives of Allergy and Immunology154:4, 286-2941018-2438

Internetlänk

Länkade data-URI:er (test)

  • 324597 (Evaldsson, Chamilly 1978- aut)
  • 347333 (Linköpings universitet Institutionen för klinisk och experimentell medicin pbl)
Inställningar Hjälp

Beståndsinformation saknas

Om LIBRIS
Sekretess
Blogg
Hjälp
Fel i posten?
Kontakt
Teknik och format
Sök utifrån
Sökrutor
Plug-ins
Bookmarklet
Anpassa
Textstorlek
Kontrast
Vyer
LIBRIS söktjänster
SwePub
Sondera
Uppsök

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy