Startsida
Hjälp
Sök i LIBRIS databas

     

 

Sökning: onr:22151910 > Isomaltitol exacerb...

Isomaltitol exacerbates neutrophilia but reduces eosinophilia [Elektronisk resurs] New insights into the Sephadex model of lung inflammation

Evaldsson, Chamilly 1978- (författare)
Rydén, Ingvar (författare)
Uppugunduri, Srinivas (författare)
Linköpings universitet Institutionen för klinisk och experimentell medicin (utgivare)
Alternativt namn: IKE
Alternativt namn: Linköping University. Department of Clinical and Experimental Medicine
Alternativt namn: Linköping University. Faculty of Health Sciences. Department of Clinical and Experimental Medicine
Linköpings universitet Hälsouniversitetet (utgivare)
Östergötlands Läns Landsting Diagnostikcentrum (utgivare)
Karger 2011
Engelska.
Ingår i: International Archives of Allergy and Immunology. - 1018-2438. ; 154:4, 286-294
Läs hela texten
Läs hela texten
Läs hela texten
Läs hela texten
  • E-artikel/E-kapitel
Sammanfattning Ämnesord
Stäng  
  • We have previously examined isomaltitol in an in vitro static adhesion assay between isolated granulocytes and cultured human umbilical cord vein cells and were interested in investigating whether the potentially anti-inflammatory effects observed there could be reproduced in vivo. The Sephadex-induced lung inflammation model was considered a suitable model due to the significant changes in global inflammatory endpoints, like oedema and leukocyte migration, usually seen upon provocation with Sephadex. Male Sprague-Dawley rats were instilled intratracheally with Sephadex (5 mg/ml), vehicle (0.9% NaCl), isomaltitol (50 mg/ml) or a combination of isomaltitol and Sephadex. After 24 h, the lungs were weighed to measure oedema and preserved for histology. Bronchoalveolar lavage fluid was used for analysis of tumour necrosis factor, cysteinyl leukotrienes, and differential and total leukocyte counts. In addition, blood differential counts and thymus weights were analysed. Contrary to what we expected from in vitro experiments, differential counts showed that isomaltitol increased the neutrophil component while decreasing the eosinophilia. Isomaltitol thus asserted a modulatory role on the usually eosinophil-dominated Sephadex-induced cell profile. Isomaltitol alone also increased several inflammatory parameters, including oedema and cysteinyl leukotrienes, and generally aggravated total inflammation in combination with Sephadex. Although the mechanisms were not investigated in this study, the effects could relate to a combination of isomaltitol's osmotic and structure-specific properties. Our results indicate that isomaltitol can modulate the inflammatory response induced by Sephadex instillation in addition to have pro-inflammatory effects on it its own, and may therefore provide new insights into the mechanisms of this widely used animal model. Sugar alcohols similar to isomaltitol have already been used to aid mucus clearance in cystic fibrosis patients, and it is possible that isomaltitol could also be used for this purpose. 

Ämnesord

Medical and Health Sciences  (hsv)
Clinical Medicine  (hsv)
Respiratory Medicine and Allergy  (hsv)
Medicin och hälsovetenskap  (hsv)
Klinisk medicin  (hsv)
Lungmedicin och allergi  (hsv)
Medical and Health Sciences  (hsv)
Basic Medicine  (hsv)
Pharmacology and Toxicology  (hsv)
Medicin och hälsovetenskap  (hsv)
Medicinska grundvetenskaper  (hsv)
Farmakologi och toxikologi  (hsv)
MEDICINE  (svep)
Dermatology and venerology,clinical genetics, internal medicine  (svep)
Internal medicine  (svep)
Lung diseases  (svep)
MEDICIN  (svep)
Dermatologi och venerologi, klinisk genetik, invärtesmedicin  (svep)
Invärtesmedicin  (svep)
Lungsjukdomar  (svep)
PHARMACY  (svep)
Pharmaceutical pharmacology  (svep)
FARMACI  (svep)
Farmaceutisk farmakologi  (svep)

Indexterm och SAB-rubrik

Isomaltitol
Sephadex
inflammation
oedema
asthma
Inställningar Hjälp

Beståndsinformation saknas

Om LIBRIS
Sekretess
Blogg
Hjälp
Fel i posten?
Kontakt
Teknik och format
Sök utifrån
Sökrutor
Plug-ins
Bookmarklet
Anpassa
Textstorlek
Kontrast
Vyer
LIBRIS söktjänster
SwePub
Sondera
Uppsök

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy