Gene expression reveals evidence for EGFR-dependent proximal-distal limb patterning in a myriapod [Elektronisk resurs]
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Janssen, Ralf 1975- (författare)
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Uppsala universitet Teknisk-naturvetenskapliga vetenskapsområdet (utgivare)
- WILEY 2017
- Engelska.
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Ingår i: Evolution & Development. - 1520-541X. ; 19:3, 124-135
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- Evolution of segmented limbs is one of the key innovations of Arthropoda, allowing development of functionally specific specialized head and trunk appendages, a major factor behind their unmatched evolutionary success. Proximodistal limb patterning is controlled by two regulatory networks in the vinegar fly Drosophila melanogaster, and other insects. The first is represented by the function of the morphogens Wingless (Wg) and Decapentaplegic (Dpp); the second by the EGFR-signaling cascade. While the role of Wg and Dpp has been studied in a wide range of arthropods representing all main branches, that is, Pancrustacea (=Hexapoda+Crustacea), Myriapoda and Chelicerata, investigation of the potential role of EGFR-signaling is restricted to insects (Hexapoda). Gene expression analysis of Egfr, its potential ligands, and putative downstream factors in the pill millipede Glomeris marginata (Myriapoda: Diplopoda), reveals thatin at least mandibulate arthropodsEGFR-signaling is likely a conserved regulatory mechanism in proximodistal limb patterning.
Ämnesord
- Natural Sciences (hsv)
- Biological Sciences (hsv)
- Naturvetenskap (hsv)
- Biologiska vetenskaper (hsv)
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