Comparative genomic analysis of  Lactobacillus mucosae  LM1 identifies potential niche-specific genes and pathways for gastrointestinal adaptation [Elektronisk resurs]

• Lactobacillus mucosae  is currently of interest as putative probiotics due to their metabolic capabilities and ability to colonize host mucosal niches.  L. mucosae  LM1 has been studied in its functions in cell adhesion and pathogen inhibition,  etc.  It demonstrated unique abilities to use energy from carbohydrate and non-carbohydrate sources. Due to these functions, we report the first complete genome sequence of an  L. mucosae  strain,  L .  mucosae  LM1. Analysis of the pan-genome in comparison with closely-related  Lactobacillus  species identified a complete glycogen metabolism pathway, as well as folate biosynthesis, complementing previous proteomic data on the LM1 strain. It also revealed common and unique niche-adaptation genes among the various  L. mucosae  strains. The aim of this study was to derive genomic information that would reveal the probable mechanisms underlying the probiotic effect of  L. mucosae  LM1, and provide a better understanding of the nature of  L. mucosae  sp. 

Ämnesord

Natural Sciences  (hsv)

Biological Sciences  (hsv)

Microbiology  (hsv)

Naturvetenskap  (hsv)

Biologiska vetenskaper  (hsv)

Mikrobiologi  (hsv)

Genre

government publication  (marcgt)

Indexterm och SAB-rubrik

Lactobacillus mucosae

Comparative genomics

Probiotics