Saliva and Serum Immune Responses in Apical Periodontitis [Elektronisk resurs]
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Pietiäinen, Milla (författare)
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Liljestrand, John M. (författare)
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Akhi, Ramin (författare)
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Buhlin, Kåre (författare)
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Johansson, Anders, 1955- (författare)
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Paju, Susanna (författare)
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Salminen, Aino (författare)
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Mäntylä, Päivi (författare)
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Sinisalo, Juha (författare)
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Tjäderhane, Leo (författare)
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Hörkkö, Sohvi (författare)
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Pussinen, Pirkko J. (författare)
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Aa-gruppen (medarbetare)
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Umeå universitet Medicinska fakulteten (utgivare)
- Publicerad: Basel, Switzerland : MDPI, 2019
- Engelska.
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Ingår i: ; 8:6
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- Relaterad länk:
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http://www.umu.se/ (Värdpublikation)
Sammanfattning
Ämnesord
Stäng
- Apical periodontitis is an inflammatory reaction at the apex of an infected tooth. Its microbiota resembles that of marginal periodontitis and may induce local and systemic antibodies binding to bacteria- and host-derived epitopes. Our aim was to investigate the features of the adaptive immune response in apical periodontitis. The present Parogene cohort ( n = 453) comprises patients with cardiac symptoms. Clinical and radiographic oral examination was performed to diagnose apical and marginal periodontitis. A three-category endodontic lesion score was designed. Antibodies binding to the bacteria- and host-derived epitopes were determined from saliva and serum, and bacterial compositions were examined from saliva and subgingival samples. The significant ORs (95% CI) for the highest endodontic scores were observed for saliva IgA and IgG to bacterial antigens (2.90 (1.01-8.33) and 4.91 (2.48-9.71)/log10 unit), saliva cross-reacting IgG (2.10 (1.48-2.97)), serum IgG to bacterial antigens (4.66 (1.22-10.1)), and Gram-negative subgingival species (1.98 (1.16-3.37)). In a subgroup without marginal periodontitis, only saliva IgG against bacterial antigens associated with untreated apical periodontitis (4.77 (1.05-21.7)). Apical periodontitis associates with versatile adaptive immune responses against both bacterial- and host-derived epitopes independently of marginal periodontitis. Saliva immunoglobulins could be useful biomarkers of oral infections including apical periodontitis-a putative risk factor for systemic diseases.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- immunologi (umu)
- Immunology (umu)
Genre
- government publication (marcgt)
Indexterm och SAB-rubrik
- adaptive immunity
- antibody
- apical periodontitis
- saliva
- serum
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