Salivary IgA response to probiotic bacteria and mutans streptococci after the use of chewing gum containing Lactobacillus reuteri [Elektronisk resurs]
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Ericson, Dan (författare)
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Hamberg, Kristina (författare)
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Bratthall, Gunilla (författare)
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Sinkiewicz-Enggren, Gabriela (författare)
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Ljunggren, Lennart (författare)
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Malmö högskola Fakulteten för hälsa och samhälle (HS) (utgivare)
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Malmö högskola Odontologiska fakulteten (OD) (utgivare)
- Publicerad: Wiley-Blackwell, 2013
- Engelska.
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Ingår i: Pathogens and Disease. ; 68:3, 82-87
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Sammanfattning
Ämnesord
Stäng
- We investigated whether ingestion of probiotic bacteria could influence salivary IgA levels, specific anti-mutans streptococci IgA levels and specific antibodies towards the ingested probiotic bacterium. The study was a randomised, double-blind, placebo-controlled trial, where the test group (n = 11) received twice daily chewing of gum containing Lactobacillus reuteri (2 9 108 CFU per dose) and the control group (n = 12) received placebo. Resting saliva was collected before and after 12 weeks of treatment and 4 weeks after end of treatment. Total salivary IgA concentrations were measured by ELISA. Specific IgA reactivity was determined using a whole-cell ELISA. Results were expressed as % IgA per protein in saliva. The level of total IgA% per protein increased significantly between pretreatment levels (13.5%) and follow-up treatment levels (14.4%) within the test group only (P < 0.05). No changes were seen in the control group during the trial. The level of probiotic-reactive antibodies decreased significantly between pre- and post-treatment samples (from 12.2% to 9.0%, P < 0.05) in the test group. Similarly, the level of specific mutans streptococci antibodies decreased significantly between pre- and post-treatment samples (P < 0.05) in the test group only (for Streptococcus mutans from 20.1% to 15.0%; for Streptococcus sobrinus from 7.4% to 5.3%). Ingestion of probiotic bacteria might influence the adaptive immune response of the host.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Dentistry (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Odontologi (hsv)
Genre
- government publication (marcgt)
Indexterm och SAB-rubrik
- probiotics
- salivary IgA
- mutans streptococci
- Lactobacillus reuteri
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Pathogens and Disease